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Acne Cystic Lesion

Do antibiotics for acne make it worse when stopped?


I have mild/moderate acne.

It pretty much is only cystic lesions on my chin... but is virtually nowhere else on my face with the exception of a few bumps here and there

I have been prescribed Doryx to treat it

I worry that by taking an oral antibiotic that it may just make it worse in the long run....

Its not good now, but I don't think I could handle it if it got worse...

Can antibiotics make acne worse when you stop taking them? Or even while taking them? Could it reduce my body's ability to control the acne bacteria on it's own?
I've been taking for 3 days now... would it be bad to stop now?

it wont get worse at all. and take multi vitamins along with the medications. nothing will happen. ive been on them.



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Cystic Acne Cases and Acne Scars


The Pathogenesis of Acne Part 2

Four Pathogenic Factors in Acne
o Excessive secretion of sebum is a necessary prerequisite for the onset of acne.
o Epithelial cells in the sebaceous follicles undergo abnormal desquamation. The combination of abnormally desquamated cells and excessive sebum form a microcomedo the precursor lesion of both no inflammatory comedones and inflammatory lesions.
o The anaerobic bacterium Propionibacterium acnes proliferates in the lipid-rich environment of the microcomedo.
o Acne produces proinflammatory mediators and chemotactic factors that can cause microcomedones to inflame and evolve into papules, pustules, and nodules.
Hormones in Acne
o Most acne patients probably have sebaceous glands that are hypersensitive to the effects of androgens.
o The most important hormones in the pathogenesis of acne are testosterone and dihydrotestosterone (DHT).
o Women with signs of virilization may have excess androgen production and need to undergo a hormonal work-up.
Topical Retinoids Render Follicles Inhospitable to P acnes
o Topical retinoids such as adapalene (Differin®), or tretinoin (Retin-A®, Retin-A MicroTM, or Avita®) are the treatment of choice for normalizing follicular epithelial desquamation and making the environment less favorable for P acnes proliferation.
o The application of adapalene or tretinoin results in a "less plugged" follicle.
o To achieve optimal results, topical retinoids should be used for several months.
o Combination therapy with antibiotics, either topically or systemically, makes sense for most patients.
Treating Acne
o For mild inflammatory acne: daily applications of a topical retinoid along with a combination of benzoyl peroxide with erythromycin.
o For mild to moderate inflammatory acne, either adapalene or tretinoin with benzoyl peroxide, or topical retinoids with a combination of benzoyl peroxide/erythromycin.
o Depending on severity, some patients may need to use both an oral and a topical version of a single antibiotic.
o Patients with large lesions can be treated with a local injection of a corticosteroid.
o Patients with nodular, cystic lesions may respond to oral antibiotic therapy alone. Some may require the systemic retinoid isotretinoin. In women, hormonal therapy with or without spironolactone is another option.
o For women with excessive ovarian androgen production, oral contraceptives containing estrogens or progestins are a good choice.
o Acne fulminans usually responds to oral corticosteroids.
o Acne surgery can be used if there are a large number of comedones, and the patient has applied topical retinoids for 1 to 2 months.

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