Adult Acne Clinical Trials

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Health Care Stakeholder Discussion: Physicians


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Doxycycline Vibramycin is a tetracycline antibiotic. It works by slowing the growth of bacteria in the body. Doxycycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, and chlamydia, periodontitis (gum disease), and others. It may be used in combination with other medicines to treat certain amoeba infections.

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Oral Antibiotics

Antibiotics are used topically as well as orally. For severe acne oral antibiotics are used as they produce quicker results. Broad-spectrum antibiotics kill the bacteria P.acnes. With reduction in the population of this bacterium, infection and inflammation reduces. Tetracycline, erythromycin and Doxycycline are commonly used antibiotics. Excessive use of antibiotics can cause resistance to the antibiotic and gastro intestinal problems.

Teenagers and young adults who are suffering with acne don't particularly care what a treatment for acne is called. All they want to know is if it will work! That's understandable. Acne feels a lot like the plague to young people. They feel ugly and the most important thing to them is for the acne to be gone!

The most common used oral antibiotics for treating Rosacea and keeping it under control are Tetracycline, Doxycycline and Metronidazole. Benefic effects on the skin eruptions specific for Rosacea seems to have the topical use gel containing Metronidazole. This product is however irritant for some of the patients producing symptoms like burning and stinging. Thus, in some other cases, topically used Metronidazole seems to help reduce facial erythema and teleangiectasie. Metronidazole cannot be administered during pregnancy and must be replaced with the also benefic topical product called Clindamycin. Oral tetracycline and Metronidazole are also forbidden during the pregnancy period due to its teratogenic effects.

Most dermatologists prescribe topical antibiotics such as Retin-A or Benzoyl Peroxide or oral antibiotics such as Tetracycline, Minocycline, or Doxycycline in order to heal cystic acne. Among the more popular treatments for prescribed medication is Isotretinoin, also known as Accutane. Isotretinoin treatment helps treat excess oil, clogged pores, inflammation, and P. bacteria. Because of the amount of Vitamin A, the drawback of Isotretinoin can cause dryness of skin, headaches, hair thinning, and back pains as well as other side effects.

That's why instead of relying on medication, an internal treatment that involves heavy detoxification may be a better choice. Two things that come in mind when dealing with heavy detoxification are water hydration and juice cleansing.

The choice of treatment depends on the severity of condition. A patient with mild acne should receive topical therapy. In moderate-to-severe acne, systemic treatment is required in most cases, using antibiotics, and oral retinoids. As a first line treatment, most doctors recommend the use of antibiotics, including tetracyclines, Doxycycline, minocycline, and erythromycin. Recently, azithromycin has been added to this list. Comparative clinical trials have shown that the tolerability of azithromycin is superior to that of erythromycin and Doxycycline. Moreover, tetracyclines can cause both mucocutaneous and systemic side effects.

The unique pharmacological properties of azithromycin, together with its effectiveness, make it a highly suitable medication for the treatment of acne. The drug shows anti-inflammatory effects and demonstrates activity against many bacteria, including Propionibacterium acnes.

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